Year: 2012
Type: conference-abstract
Abstract: Background. Worldwide lung cancer incidence is decreasing or leveling off among men, but rising among women. Gender differences in the effect of tobacco carcinogens on lung cancer risk have been hypothesized, but the epidemiologic evidence is conflicting. Objective. To test gender-smoking interaction in the association with lung cancer risk within the large Environment And Genetics in Lung cancer Etiology (EAGLE) population-based case-control study, conducted in Italy between 2002-2005. The study collected detailed lifetime smoking histories by personal interview. Methods. Separately for males and females, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) for cumulative exposure to smoking (pack-years) by logistic regression, adjusted for age, residence area, and time since quitting smoking. We evaluated several potential confounders and effect-modifiers, including tobacco type, inhalation depth, percentage of each cigarette smoked, and visualized the tobacco dose-response relationship across genders through floating trends. We tested gender-smoking interaction (female versus male effect) by including their product term in the models. Results. When the model included never smoker cases and controls, ORs for categories of pack-years were higher in men, with a negative female-smoking interaction (P=0.0009). Within ever smokers, ORs estimates were somewhat higher in women, but the test for interaction was not significant (P=0.55). We obtained similar results for pack-years as a continuous (log-transformed) variable. Among smokers, no gender-smoking interaction was found by histology. Conclusion. Our findings do not support a higher female susceptibility to tobacco-related lung cancer. Equally vigorous health policy interventions should continue to fight smoking habits in both genders. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 630. doi:1538-7445.AM2012-630
Source: Cancer Research
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Università degli Studi di Milano, Fondazione Cariplo, Ministero della Salute, Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro, Regione Lombardia, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Award: G6598259231
OpenAlex ID: W2022073637