Work

Acid‐Promoted Retro‐Mannich Reaction of N‐Protected Tropenones to 2‐Substituted Pyrroles

Year: 2004

Type: article

Abstract: N‐protected tropenone 4 undergoes highly regioselective retro‐Mannich reactions to 2‐pyrrolyl ketones 5 and 7 in the presence of Lewis or Brønsted acids. Analogously, the pyrrole derivative 8a was obtained by using subsequent nucleophilic trapping with TMSCN. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.200300804

Authors: Nicolai Cramer, Jeannette Juretschke, Sabine Laschat, Angelika Baro, Wolfgang Frey

Institution: University of Stuttgart

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Deutsche Forschungsgemeinschaft

OpenAlex ID: W2022127715

FWCI: 1.057

Cites: 23

Cited by: 24

Related to: 10