Concepts in in vivo siRNA delivery for cancer therapy
Year: 2009
Type: review
Abstract: In vivo gene silencing using RNAi plays an important role in target validation and is advancing towards the development of RNAi-based therapeutics. RNAs were thought to have just two broad functions in cells as messenger RNAs (mRNAs) and ribosomal RNAs, but recently the relevance of microRNAs is becoming more clearly understood. mRNA molecules transmit information between DNA and protein and, as such, are vital intermediaries for gene expression. Ribosomal and transfer RNAs have structural, catalytic, and information-decoding roles in the process of protein synthesis, whereas microRNAs are regulators of gene expression. This review presents the early and intriguing successes of using siRNAs for in vivo gene silencing and its use as a possible cancer therapeutics.
Source: Journal of Cellular Physiology
DOI: 10.1002/jcp.21790
Authors: Christopher S. Gondi, Jasti S. Rao
Institution: Peoria campus of the University of Illinois System
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1320390427, G2424367518, Regression of meningioma tumor growth by combination therapy, Suppression of glioma invasion by a bicistronic constuct, G3760626908, G3941523583, G4091456469, G4366939855, Role of TFPI-2 in human gliomas invasiveness, Role of uPA and uPAR in Human Glioma Invasiveness, G4770781718, Growth inhibition of brain tumors by cord blood stem cells, Inhibition of glioma tumor growth by antisense MMP-9, Cath B and uPAR si RNA constructs regressed glioma growth
OpenAlex ID: W2022179846