Work

The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development

Year: 2008

Type: article

Abstract: BACKGROUND: Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes. PRINCIPAL FINDINGS: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. SIGNIFICANCE: Mych is a novel factor required for neural crest cell survival in zebrafish.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0002029

Authors: Sung-Kook Hong, Michael Tsang, Igor B. Dawid

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Pittsburgh

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,382

Funders: National Institutes of Health, National Institute of Child Health and Human Development