Year: 2011
Type: article
Abstract: Alzheimer's Disease (AD) is the most common dementia in the elderly and is estimated to affect tens of millions of people worldwide. AD is believed to have a prodromal stage lasting ten or more years. While amyloid deposits, tau filaments, and loss of brain cells are characteristics of the disease, the loss of dendritic spines and of synapses predate such changes. Popular preclinical detection strategies mainly involve cerebrospinal fluid biomarkers, magnetic resonance imaging, metabolic PET scans, and amyloid imaging. One strategy missing from this list involves neurophysiological measures, which might be more sensitive to detect alterations in brain function. The Magnetoencephalography International Consortium of Alzheimer's Disease arose out of the need to advance the use of Magnetoencephalography (MEG), as a tool in AD and pre-AD research. This paper presents a framework for using MEG in dementia research, and for short-term research priorities.
DOI: 10.4061/2011/280289
Institutions: University of Utah, Universidad Complutense de Madrid, Universidad Politécnica de Madrid, University of Helsinki, Helsinki University Hospital, Center for the Neural Basis of Cognition, Carnegie Mellon University, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Pittsburgh
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $820
OpenAlex ID: W2022563718