Work

MassSieve: Panning MS/MS peptide data for proteins

Year: 2010

Type: article

Abstract: We present MassSieve, a Java-based platform for visualization and parsimony analysis of single and comparative LC-MS/MS database search engine results. The success of mass spectrometric peptide sequence assignment algorithms has led to the need for a tool to merge and evaluate the increasing data set sizes that result from LC-MS/MS-based shotgun proteomic experiments. MassSieve supports reports from multiple search engines with differing search characteristics, which can increase peptide sequence coverage and/or identify conflicting or ambiguous spectral assignments.

Source: PROTEOMICS

DOI: 10.1002/pmic.200900370

Authors: Douglas J. Slotta, Melinda A. McFarland, Sanford P. Markey

Institutions: National Institutes of Health, National Institute of Mental Health

Language: English

Topic: Advanced Proteomics Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Mental Health

Award: Methods In Mass Spectrometry