Work

Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

Year: 1996

Type: article

Abstract: We examined long-term potentiation (LTP) at synapses between hippocampal neurons in dissociated cell culture following presynaptic, postsynaptic, or extracellular application of a nitric oxide (NO) scavenger, an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysis with UV light. Our results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts as a retrograde messenger during LTP.

Source: Journal of Physiology-Paris

DOI: 10.1016/s0928-4257(97)87907-7

Authors: O Arancio, V Lev-Ram, R.Y. Tsien, E.R. Kandel, R.D. Hawkins

Institutions: Columbia University, University of California San Diego, Howard Hughes Medical Institute, New York State Psychiatric Institute

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of Mental Health

Awards: GENETIC APPROACHES TO NEURAL &BEHAVIORAL PLASTICITY, G3316322229