Work

Induced Pluripotent Stem Cells at Nanoscale

Year: 2009

Type: article

Abstract: Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy. Both cell types are almost indistinguishable at the ultrastructural level, providing further evidence for the similarity of these 2 pluripotent stem cell populations.

Source: Stem Cells and Development

DOI: 10.1089/scd.2009.0159

Authors: Dagmar Zeuschner, Karina Mildner, Holm Zaehres, Hans R. Schöler

Institution: Max Planck Institute for Molecular Biomedicine

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2022936555

FWCI: 2.279

Cites: 15

Cited by: 38

Related to: 10