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Rational Engineering of Human Cytochrome P450 2B6 for Enhanced Expression and Stability: Importance of a Leu264→Phe Substitution

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Year: 2007
Type: article
Source: Molecular Pharmacology
DOI: 10.1124/mol.107.039693
Authors: Santosh Kumar, Yonghong Zhao, Ling Sun, Surendra S. Negi, James R. Halpert, B.K. Muralidhara
Institutions: The University of Texas Medical Branch at Galveston, Pfizer (United States)
Language: English

Topic: Pharmacogenetics and Drug Metabolism
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences

Open Access status: closed

Funder: National Institute of Environmental Health Sciences
Awards: Molecular Mechanisms of Environmental Injury, Cellular Response Mechanisms to Environmental Challenge, G1612036029, G3119154873, Molecular basis of selective P450 2B function, G7276094181
OpenAlex ID: W2022998170
FWCI: 3.377
Cites: 45
Cited by: 31
Related to: 10
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