Work

Selective androgen receptor modulators in preclinical and clinical development

Year: 2008

Type: article

Abstract: Androgen receptor (AR) plays a critical role in the function of several organs including primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable therapeutic target. Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produce less of a growth effect on prostate and other secondary sexual organs. SARMs provide therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, or end-stage renal disease, osteoporosis, frailty, and hypogonadism. This review summarizes the current standing of research and development of SARMs, crystallography of AR with SARMs, plausible mechanisms for their action and the potential therapeutic indications for this emerging class of drugs.

Source: Nuclear Receptor Signaling

DOI: 10.1621/nrs.06010

Authors: Ramesh Narayanan, Michael L. Mohler, Casey E. Bohl, Duane D. Miller, James T. Dalton

Institution: GTx (United States)

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2023115772

FWCI: 8.066

Cites: 188

Cited by: 158

Related to: 10