Work

Chiral Allene-Containing Phosphines in Asymmetric Catalysis

Year: 2011

Type: article

Abstract: We demonstrate that allenes, chiral 1,2-dienes, appended with basic functionality can serve as ligands for transition metals. We describe an allene-containing bisphosphine that, when coordinated to Rh(I), promotes the asymmetric addition of arylboronic acids to α-keto esters with high enantioselectivity. Solution and solid-state structural analysis reveals that one olefin of the allene can coordinate to transition metals, generating bi- and tridentate ligands.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja207748r

Authors: Feng Cai, Xiaotao Pu, Xiangbing Qi, Vincent Lynch, Akella Radha, Joseph M. Ready

Institutions: The University of Texas Southwestern Medical Center, The University of Texas at Austin

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources

Awards: Catalytic Synthesis of alpha-Branched Carbonyl Compounds, G5564226626, Resource for Biocomputing, Visualization, and Informatics