Year: 2013
Type: review
Abstract: Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map .
Source: Molecular Neurobiology
Authors: Kazuhiro A. Fujita, Marek Ostaszewski, Yukiko Matsuoka, Samik Ghosh, Enrico Glaab, Christophe Trefois, Isaac Crespo, Thanneer M. Perumal, Wiktor Jurkowski, Paul M. A. Antony, Nico Diederich, Manuel Buttini, Akihiko Kodama, Venkata P. Satagopam, Serge Eifes, Antonio del Sol, Reinhard Schneider, Hiroaki Kitano, Rudi Balling
Institutions: Systems Biology Institute, University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Integrated Biobank of Luxembourg, Centre Hospitalier de Luxembourg, Tokyo Medical and Dental University, European Molecular Biology Laboratory, European Molecular Biology Laboratory, Okinawa Institute of Science and Technology Graduate University, Sony Computer Science Laboratories
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,590
OpenAlex ID: W2023250031