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Bone morphogenetic protein: Chromosomal localization of human genes for BMP1, BMP2A, and BMP3

Year: 1991
Type: article
Abstract: Bone morphogenetic protein (BMP) induces endochondral bone formation in vivo. The human genes have been cloned for a group of proteins containing BMP activity (BMP1, BMP2A, and BMP3). Two of the proteins are members of the transforming growth factor-beta supergene family (BMP2A and BMP3), while BMP1 is a novel regulatory protein. Using somatic cell hybrid lines, cDNA probes were used to map BMP1 to chromosome 8, BMP2A to chromosome 20, and BMP3 to the p14-q21 region of chromosome 4. This analysis reveals that the BMP2A and BMP3 genes map to conserved regions between mouse and human, while the BMP1 gene does not. The locations of the BMP genes were found to overlap with the loci for several disorders of cartilage and bone formation.
Source: Genomics
DOI: 10.1016/0888-7543(91)90254-c
Authors: Jeffrey A. Tabas, Michael Zasloff, John J. Wasmuth, Beverly S. Emanuel, Michael R. Altherr, John D. McPherson, John M. Wozney, Frederick S. Kaplan
Language: English
Open Access status: hybrid
Estimated APC paid: $2,980
Funders: Hartford Foundation for Public Giving, International Fibrodysplasia Ossificans Progressiva Association, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources
OpenAlex ID: W2023256290
FWCI: 2.775
Cites: 34
Cited by: 69
Related to: 10