The structure of the human β-globin gene in β-thalassaemia
Year: 1979
Type: article
Study design: Observational Study
Abstract: Twenty-one cases of beta 0 and beta +-thalassaemia have been analysed by restriction endonuclease mapping. In most cases no deletion in the regions surrounding the beta- and delta-globin genes could be detected. However, in a single Asian case of beta 0-thalassaemia, homozygous clinically, one of the homologous chromosomes contained a beta-globin gene with a deletion of 600 base pairs of DNA and comprising most or all of the 3' end of the structural gene including the EcoRI restriction site within the beta-globin coding sequence.
Source: Nucleic Acids Research
DOI: 10.1093/nar/6.8.2749
Institutions: University of Amsterdam, University of London, St Mary's Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2023557756