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Lymphoma with clonal T-cell receptor gene rearrangement in a 25-year survivor of Hodgkin's disease

Year: 1987

Type: article

Abstract: A woman was treated for Hodgkin's disease, remained disease-free for 25 years, and then developed waxing and waning adenopathy during the next 2 years. The histologic examination of a lymph node biopsy specimen showed a T-cell non-Hodgkin's lymphoma. The patient's indolent clinical course prompted a second biopsy to obtain tissue for T-cell receptor gene rearrangement studies. A southern blot analysis using a human T-cell receptor beta chain probe showed a new band of rearranged DNA, which confirmed the diagnosis of T-cell lymphoma.

Source: Cancer

DOI: 10.1002/1097-0142(19871101)60:9<2213::aid-cncr2820600918>3.0.co;2-j

Authors: Frederick P. Li, Kathreen Gimbrere, Jerome Ritz, Haruo Saito, Janina A. Longtine

Institutions: Dana-Farber Cancer Institute, National Cancer Institute, Brigham and Women's Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2023656223

FWCI: 0.654

Cites: 34

Cited by: 5

Related to: 10