Work

Spectroscopic Characterization of Bendazac and Benzydamine: Possible Photochemical Modes of Action

Year: 1996

Type: article

Abstract: The involvement of near-UV light in cataract development suggests that potential anti-cataract drugs may display unusual spectroscopic properties. As bendazac impedes certain effects associated with lens opacification, we have characterized the singlet and triplet states of bendazac and its analog, benzydamine, by fluorescence and phosphorescence methods. These compounds have much shorter triplet state lifetimes compared to the triplet state lifetimes observed in proteins. Our results raise the possibility that the photoprotective action of these compounds may result from their ability to dissipate energy through the triplet state. We propose alternative modes for the photoprotective actions of these compounds.

Source: Biochemical and Biophysical Research Communications

DOI: 10.1006/bbrc.1996.0584

Authors: Joseph M. Jez, Jane M. Vanderkooi, Alan M. Laties

Institution: University of Pennsylvania

Language: English

Topic: Photochemistry and Electron Transfer Studies

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,110