Year: 1987
Type: article
Abstract: Table Control Alzheimer'.s disease Means + SEM (n) Means + SEM (n) p (ANOVA) Occipital cortex 22-5 + 3-6 (6) 90 + 20 (5) <0-02 Parietal cortex 20 1 + 3 0 (6) 8 8 + 2-3 (6) < 0-02 Frontal cortex 32 1 + 5-5 (7) 11 4 + 19 (5) <002 Temporal cortex 27-1 + 4 9 (7) 8-3 + 2 0 (7) < 0-02 Hippocampus 178 + 78(5) 60 + 20(7) <005 Caudate 14 5 + 3 0 (6) 8-0 + 3 4 (4) NS Globus pallidus 10 3 + 4 8 (4) 10 2 + 4 2 (3) NS Putamen 13 2 + 2 5 (5) 8-4 + 5-0 (2) NS We interpret these results as indicating a severe (60%) loss of glutamate terminals in cortical and hippocampal regions in Alzheimer's disease with little or no loss of glutamate innervation in subcortical regions.These results suggest a large glu- tamatergic deficit in Alzheimer's disease consistent with the pathology of the disorder.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2024094381