Work

Herpes Simplex Virus Keratitis: Histopathologic Neovascularization and Corneal Allograft Failure

Year: 2009

Type: article

Abstract: PURPOSE: To identify whether histopathologic presence of neovascularization is predictive for allograft failure following penetrating keratoplasty for herpes simplex virus (HSV) keratitis. METHODS: Retrospective, interventional case series of 62 consecutive patients with HSV keratitis who underwent penetrating keratoplasty at the Kellogg Eye Center between 1990 and 2000. Reviews of the patients' clinical charts and the histopathologic slides of their excised corneal buttons were performed to identify associations between histopathologic neovascularization and clinical outcomes. MAIN OUTCOME MEASURE: To determine whether histopathologic presence of neovascularization predicts allograft failure. RESULTS: Histopathologic presence of neovascularization was present in 31% of corneal specimens and predicted subsequent allograft failure (P = 0.002) and HSV recurrence (P = 0.05). CONCLUSION: Histopathologic presence of neovascularization is a risk factor for corneal allograft failure and HSV recurrence.

Source: Cornea

DOI: 10.1097/ico.0b013e31819c4e55

Authors: Denise D Garcia, Roni M Shtein, David C Musch, Victor M Elner

Institutions: National Institutes of Health, University of Michigan

Language: English

Topic: Corneal surgery and disorders

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute