Work

Angiogenesis: A Harmonized Target for Recovery After Stroke

Year: 2012

Type: review

Abstract: I t is now appreciated that emerging therapeutic strategies for recovery must include the cerebral vasculature and that induction of angiogenesis will stimulate endogenous recovery mechanisms, including neurogenesis, synaptogenesis, and neuronal and synaptic plasticity.These events are all involved in the long-term repair and restoration process of the brain after an ischemic event.Several recent excellent reviews provided detailed information on the mechanisms and molecular targets for angiogenesis after stroke.1,2 The purpose of this review is to evaluate the evidence that angiogenesis is a target for recovery after an ischemic stroke.

Source: Stroke

DOI: 10.1161/strokeaha.111.642710

Authors: Adviye Ergul, Ahmed Alhusban, Susan C. Fagan

Institution: Charlie Norwood VA Medical Center

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Veterans Affairs, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke