Year: 2014
Type: review
Abstract: The ability to adapt to cycles of feast and famine is critical for survival. Communication between multiple metabolic organs must be integrated to properly metabolise nutrients. By controlling networks of genes in major metabolic organs, nuclear hormone receptors (NHRs) play central roles in regulating metabolism in a tissue-specific manner. NHRs also establish daily rhythmicity by controlling the expression of core clock genes both centrally and peripherally. Recent findings show that many of the metabolic effects of NHRs are mediated through certain members of the fibroblast growth factor (FGF) family. This review focuses on the roles of NHRs in critical metabolic organs, including adipose tissue, liver and muscle, during the fed and fasted states, as well as their roles in circadian metabolism and downstream regulation of FGFs.
Source: Diabetologia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,490
Funders: Howard Hughes Medical Institute, Ellison Medical Foundation, March of Dimes Foundation, Glenn Foundation for Medical Research, Leona M. and Harry B. Helmsley Charitable Trust, Fondation pour la Recherche Médicale, Ipsen, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: G114280915, Hormonal Regulation of Mammalian Gene Expression, G2147928738, G2506757200, G2732016543, DETECTION AND MODELS OF TOXICANT EXPOSURE, G350971196, Hormonal Regulation of Mammalian Gene Expression, G4229701413, Spatial Regulation of Developmental Gene Expression, G4542402193, Molecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin Resistance, G4975243971, G636335003, G637574655, Role of Immune Mechanisms in Athersclerosis and Inflammation, G8221331289, G8568421125, G9000055537, G9000076190, G9000105172, G9000241332, G9000273664, Cancer Center Support Grant (CCSG)
OpenAlex ID: W2024390103