Work

Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas

Year: 2010

Type: article

Abstract: The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurrent malignant gliomas, suggesting that patient therapy should perhaps be tailored specifically against the predominant vasculature pathway at a given specific stage of gliomagenesis.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci42345

Authors: Jeffrey P. Greenfield, William S. Cobb, David Lyden

Institutions: Children's Cancer and Blood Foundation, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze