Work

Bioplasmonic Paper as a Platform for Detection of Kidney Cancer Biomarkers

Year: 2012

Type: article

Abstract: We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.

Source: Analytical Chemistry

DOI: 10.1021/ac302332g

Authors: Limei Tian, Jeremiah J. Morrissey, Ramesh Kattumenu, Naveen Gandra, Evan D. Kharasch, Srikanth Singamaneni

Institution: Washington University in St. Louis

Language: English

Topic: Biosensors and Analytical Detection

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: NANOTECH BIOMARKERS FOR RENAL CANCER INTERVENTION: CLINICAL VALIDATION & UTILITY, G599563037