Work

Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries

Year: 2008

Type: article

Abstract: Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 microm and an imaging depth >0.7 mm.

Source: Optics Letters

DOI: 10.1364/ol.33.000929

Authors: Konstantin Maslov, Hao F. Zhang, Song Hu, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering