Work

Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases

Year: 1994

Type: article

Abstract: Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes.

Source: Nucleic Acids Research

DOI: 10.1093/nar/22.17.3640

Authors: Michael McClelland, Michael Nelson, Eberhard Raschke

Institution: University of Bonn

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

Awards: RNA FINGERPRINTS--DIFFERENTIAL GENE EXPRESSION IN BRAIN, Comparative Genome Analysis of Salmonella Species, G4527688447