Work

Clear cell sarcoma and selective IgM deficiency: A case report

Year: 1982

Type: article

Abstract: A case of clear cell sarcoma of tendons and aponeuroses and a co-existent IgM deficiency is reported. The tumor arose in the Achilles tendon with metastases to the skin, bone, and lymph nodes. The tumor, examined by light and electron microscopy, consisted of glycogen-containing clear cells with melanotic and amelanotic features. There was no detectable serum IgM. The IgA levels were normal and IgG levels were elevated. Peripheral blood lymphocytes contained a normal amount (4.5%) of IgM-bearing cells. Cultured mononuclear cells from the patient suppressed production of IgM by normal lymphocytes, suggesting a role of suppressor cells in the IgM deficiency. The co-existence of soft tissue sarcomas and immunoglobulin deficiency states is reviewed.

Source: Cancer

Authors: Nicholas J. Vogelzang, Howard Corwin, Jonathan L. Finlay, Edmund V. Pellettiere, Allan T. Luskin, Ralph F. Di Camelli, Richard Hong

Institutions: American Cancer Society, University of Minnesota, United States Public Health Service, National Cancer Institute, Masonic Cancer Center, Rush University Medical Center, University of Wisconsin–Madison, UW Health University Hospital

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Cancer Society, U.S. Public Health Service, National Cancer Institute

OpenAlex ID: W2024955994

FWCI: 0.526

Cites: 24

Cited by: 25

Related to: 10