Work

Study Methodologies for Osteoarthritis: Clinical Trials and Tribulations

Year: 2011

Type: article

Abstract: Clinical trials represent the most rigorous approach to evaluating the efficacy of interventions. The clinical trial is a relatively young methodology, used rarely until the middle of the twentieth century. Most clinical trials evaluate medications. In fact a review of clinicaltrials.gov in 2011 indicated that of more than 100,000 registered trials, over 70% were drug trials [1]. The remainder was divided among devices, surgery, and behavioral and educational interventions. While drug trials are important for development of therapeutics in osteoarthritis, trials of surgery, devices, and educational and behavioral interventions are critical as well.

Source: HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery

DOI: 10.1007/s11420-011-9240-1

Author: Jeffrey N. Katz

Institutions: Brigham and Women's Hospital, Harvard University

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases