Work

Cryo-EM Study of the Ribosome-Bound Release Factor 1

Year: 2005

Type: article

Abstract: Ribosomes conduct mRNA-directed synthesis of proteins according to the same principles in all organisms.In general, translation is accomplished in four steps: initiation, elongation, termination, and recycling.Termination takes place when a stop codon (UAA/UAG/UGA) is translocated into the decoding center of the ribosome.With the aid of a class-1 release factor (RF1 or RF2 in eubacteria, and eRF1 in eukaryotes), the finished peptide is released from the ribosome.In eubacteria, RF1 recognizes the stop codons UAA/UAG and RF2 recognizes UAA/UGA.In eukaryotes, a single class-1 peptide release factor, eRF1, recognizes all three stop codons.

Source: Microscopy and Microanalysis

DOI: 10.1017/s1431927605500722

Authors: U Rawat, H Gao, A Zavialov, R Gursky, M Ehrenberg, J Frank

Institutions: National Institutes of Health, Howard Hughes Medical Institute, State University of New York, University at Albany, State University of New York

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2025373497

FWCI:

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