Work

Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription

Year: 2010

Type: review

Abstract: RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.

Source: Cell Cycle

DOI: 10.4161/cc.9.18.13203

Authors: Hélène Dumay-Odelot, Stéphanie Durrieu-Gaillard, Daniel Da Silva, Robert G. Roeder, Martin Teichmann

Institutions: Université de Bordeaux, Inserm, Institut Européen de Chimie et Biologie, Rockefeller University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Agence Nationale de la Recherche, European Regional Development Fund, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Nuclear Receptor Coactivator Functions and Mechanisms, G2763956061, G5921482626, G7516234444