Work

Inside Back Cover: Discovery of Small‐Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012)

Year: 2012

Type: article

Abstract: Toll-like receptors (TLRs) play pivotal roles in innate immunity. Two key members of the TLR protein family, TLR1 (orange) and TLR2 (magenta), form a heterodimeric complex that recognizes pathogen-associated molecule patterns such as Pam3CSK4 (green) and activates inflammation response. On page 12246 ff., H. Yin and co-workers describe the new inhibitor CU-CPT22 (white), which displaces bound Pam3CSK4 from the TLR1–TLR2 complex, thus providing a valuable probe for these important signaling receptors.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201208674

Authors: Kui Cheng, Xiaohui Wang, Shuting Zhang, Hang Yin

Institution: University of Colorado Boulder

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2025522404

FWCI:

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