Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging
Year: 2008
Type: article
Abstract: The synthesis, in vitro, and in vivo behavior of tumor-homing magnetic nanoworms (NW) are described. The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.
Source: Advanced Materials
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W2025628768