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Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases

Year: 2010

Type: review

Abstract: Members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins.They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver disease (NAFLD). We also highlight the potential of NRs as targets for safe and effective therapeutic interventions.

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1038/clpt.2010.2

Authors: M Arrese, S J Karpen

Institutions: Pontificia Universidad Católica de Chile, Baylor College of Medicine

Language: English

Topic: Nuclear Receptors and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases