Work

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

Year: 2008

Type: article

Abstract: After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period. Autophagy was triggered by fertilization and up-regulated in early mouse embryos. Autophagy-defective oocytes derived from oocyte-specific Atg5 (autophagy-related 5) knockout mice failed to develop beyond the four- and eight-cell stages if they were fertilized by Atg5-null sperm, but could develop if they were fertilized by wild-type sperm. Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals.

Source: Science

DOI: 10.1126/science.1154822

Authors: Satoshi Tsukamoto, Akiko Kuma, Mirei Murakami, Chieko Kishi, Akitsugu Yamamoto, Noboru Mizushima

Institutions: Tokyo Medical and Dental University, Nagahama Institute of Bio-Science and Technology, Japan Science and Technology Agency

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2025824234

FWCI: 9.713

Cites: 23

Cited by: 645

Related to: 9