Work

Time-dependent corrections to effective rate and event statistics in Michaelis–Menten kinetics

Year: 2010

Type: article

Abstract: The authors generalise the concept of the geometric phase in stochastic kinetics to a non-cyclic evolution. Its application is demonstrated on kinetics of the Michaelis-Menten reaction. It is shown that the non-periodic geometric phase is responsible for the correction to the Michaelis-Menten law when parameters, such as a substrate concentration, are changing with time. The authors apply these ideas to a model of chemical reactions in a bacterial culture of a growing size, where the geometric correction qualitatively changes the outcome of the reaction kinetics.

Source: IET Systems Biology

DOI: 10.1049/iet-syb.2010.0064

Authors: N.A. Sinitsyn, I. Nemenman

Institutions: Los Alamos National Laboratory, New Mexico Consortium, Emory University

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2025876113

FWCI: 0.391

Cites: 25

Cited by: 6

Related to: 10