Work

Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.

Year: 1981

Type: article

Abstract: Methylation-protection studies with nucleocapsids from vesicular stomatitis virus indicate that the viral polymerase (L and NS proteins) contacts the genomic RNA template in the middle of the leader gene, 16-30 nucleotides from the 3' terminus. The data suggest that the NS protein binds to the sequence (formula, see text) and may function as an initiator protein for transcription.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.78.10.6191

Authors: J D Keene, B J Thornton, S U Emerson

Institutions: Duke University, Duke Medical Center, University of Virginia

Language: English

Topic: Virology and Viral Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: American Cancer Society, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases

Award: REPLICATIVE MECHANISMS OF THE NEGATIVE STRAND VIRUSES