Work

Immunomodulatory Effects Of Vitamin D: Implications For The Treatment Of Graft Versus Host Disease

Year: 2009

Type: article

Abstract: Allogeneic transplantation is uniquely curative for some patients with hematologic malignancies. However, morbidity and mortality due to graft versus host disease remain substantial. Persistence of host dendritic cells (DCs) in the early post transplant period plays a role in the activation of alloreactive lymphocytes and the risk of GVHD. A focus of research involves the manipulation of DC recovery post-transplant to minimize activation of alloreactive lymphocytes while preserving the graft versus disease effect.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.403