Work

Palladium-Catalyzed N-Arylation of 2-Aminothiazoles

Year: 2012

Type: article

Abstract: A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

Source: Organic Letters

DOI: 10.1021/ol300178j

Authors: Meredeth A. McGowan, Jaclyn L. Henderson, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1347613584, Development of a Palladium-Catalyzed Direct N2-Arylation of Indazoles., CATALYTIC METHODS FOR ORGANIC SYNTHESIS, Late Transition Metal Catalysts for Organic Synthesis