Work

Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies

Year: 2015

Type: article

Abstract: Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ∼5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ∼22% may yield a potential EoE diagnosis.

Source: Journal of Pediatric Gastroenterology and Nutrition

DOI: 10.1097/mpg.0000000000000740

Authors: Emily M. Stucke, Katherine E. Clarridge, Margaret H. Collins, Carol J. Henderson, Lisa J. Martin, Marc E. Rothenberg

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati

Language: English

Topic: Eosinophilic Esophagitis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green