Work

Chemokines and chemokine receptors: an overview

Year: 2009

Type: review

Abstract: Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

Source: Frontiers in bioscience

DOI: 10.2741/3261

Authors: Raffaella Bonecchi, Emanuela Galliera, Elena Monica Borroni, Massimiliano Marco Corsi, Massimo Locati, Alberto Mantovani

Institutions: University of Milan, IRCCS Humanitas Research Hospital, IRCCS Ospedale Galeazzi - Sant'Ambrogio, IRCCS Policlinico San Donato

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Fondazione Cariplo, Associazione Italiana per la Ricerca sul Cancro, Fondazione Italiana per la Ricerca sul Cancro