Year: 2004
Type: article
Abstract: Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m)=mp, the specific value of the exponent p is the object of an ongoing debate, with many mechanisms being postulated to support different predictions. We propose that multicellular tumor spheroids provide an ideal experimental model system for testing these allometric growth theories, especially under controlled conditions of malnourishment and applied mechanical stress.
Source: Applied Physics Letters
DOI: 10.1063/1.1812842
Institutions: Politecnico di Torino, University of Turin, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Córdoba, University of Puerto Rico-Mayaguez, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology, Massachusetts General Hospital
Language: English
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2026096374