Work

A complete remote-control system for reliable preparation of [18F]altanserin

Year: 1999

Type: article

Abstract: A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality.

Source: Applied Radiation and Isotopes

DOI: 10.1016/s0969-8043(98)00150-x

Authors: Ping-Zhong Tan, Ronald M. Baldwin, Robert Soufer, Pradeep K. Garg, Dennis S. Charney, Robert B. Innis

Institution: Yale University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,220

Funders: National Institutes of Health, National Institute of Mental Health, Brookhaven National Laboratory