Year: 2010
Type: article
Abstract: Cardiovascular and chronic kidney disease are epidemic throughout industrialized societies. Diabetes leads to premature cardiovascular disease and is regarded by many as the most common etiological factor for chronic kidney disease. Because most studies of blood-pressure lowering agents in people with diabetes and hypertension have been conducted in individuals who already have some target organ damage, it is unclear whether earlier intervention could prevent or delay the onset of renal or systemic vascular disease. In early disease there is only a low possibility of observing cardiovascular or renal events; thus intervention trials in this population must rely on disease markers such as microalbuminuria. Accordingly, the authors review the evidence to support the use of microalbuminuria as a disease marker in diabetic patients based on its strong association with renal and cardiovascular events, and discuss recent trials that examine the impact of preventing or delaying the onset of microalbuminuria.
Source: Journal of Clinical Hypertension
Institutions: Hospital Universitario 12 De Octubre, University at Buffalo, State University of New York, Medizinische Hochschule Hannover, Centre Hospitalier Universitaire Vaudois, University of Lausanne, University of Alabama at Birmingham, State University of New York, SUNY Downstate Health Sciences University, University of Chicago, University of Missouri
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2026100796