Year: 2013
Type: article
Abstract: Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense against C. glabrata. Dectin-2-deficient (Dectin-2(-/-)) mice were found to be more susceptible to C. glabrata infections, showing a defective fungal clearance in kidneys but not in the liver. The increased susceptibility to infection was accompanied by lower production of T helper 1 (Th1) and Th17-derived cytokines by splenocytes of Dectin-2(-/-) mice, while macrophage-derived cytokines were less affected. These defects were associated with a moderate yet significant decrease in phagocytosis of the fungus by the Dectin-2(-/-) macrophages and neutrophils. Neutrophils of Dectin-2(-/-) mice also displayed lower production of reactive oxygen species (ROS) upon challenge with opsonized C. glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen.
Source: Infection and Immunity
DOI: 10.1128/iai.01189-13
Institutions: Radboud University Medical Center, University of Aberdeen
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,048
Awards: The role and modulation of Dectin-1 function in innate and adaptive immunity., Wellcome Strategic Award for Medical Mycology and Fungal Immunology, Regulation of the biosynthesis of the cell wall skeleton of Candida albicans., Wellcome Strategic Award for Medical Mycology and Fungal Immunology, Making and breaking the cell walls of fungal pathogens., Immune consequences of red cell ageing, death and disposal, G5702163051, Hydrogen peroxide signalling in Candida albicans, Candida albicans cell surface: regulation of the host-fungus interaction., Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices, Imaging the Morphogenesis, Cell Division and Growth of Microorganisms., C-type lectins in antifungal immunity, G9000023059
OpenAlex ID: W2026106645