Work

Typical 2‐Cys peroxiredoxins – structures, mechanisms and functions

Year: 2009

Type: review

Abstract: Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.

Source: FEBS Journal

DOI: 10.1111/j.1742-4658.2009.06985.x

Authors: Andrea Hall, P. A. Karplus, Leslie B. Poole

Institutions: Oregon State University, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Environmental Health Sciences

Awards: Reducing Susceptibility to Environmental Stress Throughout the Life Span, Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins