Work

952. Human Mesenchymal Stem Cells Migrate to Colon Cancer Xenografts: Potential Carriers of Cancer Therapeutics

Year: 2006

Type: article

Abstract: Mesenchymal stem cells (MSC) are found in the bone marrow and give rise to adipocytes, osteocytes, chondrocytes, and potentially other tissues. It has recently been shown that MSCs have affinity for lung and glioma tumors in xenograft models. We investigated MSC migration to colon cancer xenografts in conjunction with MSC transduction by a lentiviral vector as a way to deliver cancer therapeutics to the local tumor microenvironment. Subcutaneous colon or glioma tumor xenografts were generated in nude mice followed by intravenous infusion of DiOC18 fluorescently labeled MSCs.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.1044

Authors: Steven P. Zielske, Theodore S. Lawrence

Institution: University of Michigan

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500