Work

The incredible shrinking world of DNA microarrays

Year: 2008

Type: review

Abstract: The efficacy of microarrays in examining gene expression, gene and genome structure, protein-DNA interactions, whole-genome similarities and differences, microRNA expression, methylation (and more) is no longer in question. It is a fast-developing, cutting edge technology that has grown up along with massive sequence databases and is likely to become part of everyday patient care. Many advances have recently expanded the power and utility of microarrays; among them is our development of a new array tiling technique that dramatically increases the scope of coverage of an oligonucleotide tiling array without substantially increasing its cost.

Source: Molecular BioSystems

DOI: 10.1039/b706237k

Authors: Sarah J Wheelan, Francisco Martínez Murillo, Jef D Boeke

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Gene expression and cancer classification

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources

Awards: Transposition Mechanisms, Program on Molecular and Cellular Mechanisms of Tumorigenesis, Networks, Pathways and Dynamics of Lysine Modification