Year: 1992
Type: article
Abstract: An amino acid sequence motif, called the WD-40 repeat, has been found as a repeat in a large variety of proteins that do not share any obvious functional properties. At present, the function of the repeated motif is not known for any of these proteins. Interestingly, recent experiments in yeast indicate that several proteins containing the WD-40 repeat are genetically associated with members of the TPR-family, a protein family that is characterized by the presence of another repeated motif of unknown function: the tetratricopeptide repeat. It is conceivable that proteins containing the WD-40 repeat interact physically with members of the TPR-family via their respective repeated motifs.
Source: FEBS Letters
Authors: Loesje van der Voorn, Hidde L. Ploegh
Institution: The Netherlands Cancer Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2026649211