Work

The Group III metabotropic glutamate receptor agonist, l-AP4, reduces EPSPs in some layers of rat visual cortex

Year: 1998

Type: article

Abstract: The action of the specific Group III metabotropic glutamate receptor, l-2-amino-4-phosphonobutanoic acid (l-AP4) was tested in slices of rat visual cortex. When the predominant input to the cell was stimulated, l-AP4 generally reduced the EPSP that was produced. This result was specific to the layer: it was found when recording cells in layers II/III, V and VI, but not when recording cells in layer IV. The effect was the same when G-proteins in the cell recorded were inactivated. Also, l-AP4 had little effect on membrane potential and input impedance of the cell recorded, and little effect on the response to NMDA in that cell. Thus, Group III metabotropic glutamate receptors act presynaptically to reduce the release of glutamate onto cells in layers II/III, V and VI in visual cortex, but not cells in layer IV.

Source: Brain Research

DOI: 10.1016/s0006-8993(98)00378-3

Authors: Xiaotao Jin, Nigel W Daw

Institution: Yale University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,360

Funders: National Institutes of Health, National Eye Institute