Work

Upstream Open Reading Frames as Regulators of mRNA Translation

Year: 2000

Type: review

Abstract: Continuing discoveries of new and surprising mechanisms of gene regulation suggest that our understanding of this complex and ubiquitous biological process remains incomplete. Emerging examples illustrate that many and perhaps all genes are regulated at multiple steps including transcription, posttranscriptional processing, nuclear export and localization, stability, and translation of mature mRNA molecules. Translation itself is regulated by a diverse collection of mechanisms that act not only at the initiation step but also during elongation and termination and even after termination. Among the various cis elements in mRNAs (43) that participate in regulating translation are AUG codons within transcript leaders (upstream AUGs [uAUGs]) and, in some cases, associated upstream open reading frames (uORFs). Based on a 1987 survey, less than 10 % of eukaryotic mRNAs contain

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.20.23.8635-8642.2000

Authors: David R. Morris, Adam P. Geballe

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G1021756454, Translational Control of Cytomegalovirus Gene Expression, TRANSLATIONAL CONTROL OF ONCOPROTEIN MDM2 SYNTHESIS, Translational Control of Cytomegalovirus Gene Expression, GROWTH REGULATION OF POLYAMINE SYNTHESIS