Work

Copper-Catalyzed Arylation and Alkenylation of Polyfluoroarene C−H Bonds

Year: 2008

Type: article

Abstract: An efficient, copper-catalyzed method for the arylation, alkenylation, and benzylation of polyfluoroarenes has been developed. Arenes containing two or more fluorine substituents on the aromatic ring can be efficiently functionalized. The best results are obtained by using a combination of copper iodide catalyst, phenanthroline ligand, aryl bromide or aryl iodide coupling partner, and DMF or DMF/xylene mixed solvent.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja077862l

Authors: Hien-Quang Do, Olafs Daugulis

Institution: University of Houston

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Methods for Direct Carbon-Hydrogen Bond Functionalization