High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart
Year: 2013
Type: article
Abstract: A technique on high frame rate(28fps), high frequency co-registered ultrasound and photoacoustic imaging for visualizing zebrafish heart blood flow was demonstrated. This approach was achieved with a 40MHz light weight(0.38g) ring-type transducer, serving as the ultrasound transmitter and receiver, to allow an optic fiber, coupled with a 532nm laser, to be inserted into the hole. From the wire target study, axial resolutions of 38µm and 42µm were obtained for ultrasound and photoacoustic imaging, respectively. Carbon nanotubes were utilized as contrast agents to increase the flow signal level by 20dB in phantom studies, and zebrafish heart blood flow was successfully observed.
Source: Optics Express
DOI: 10.1364/oe.21.014636
Authors: Jinhyoung Park, Thomas M. Cummins, Michael Harrison, Jungwoo Lee, Qifa Zhou, Ching-Ling Lien, K. Kirk Shung
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,270
OpenAlex ID: W2027805563